Robins, D.L., Casagrande, K., Barton, M.L., Chen, C., Dumont-Mathieu, T., & Fein, D. (2014). Validation of the Modified Checklist for Autism in Toddlers-Revised with Follow-Up (M-CHAT-R/F). Pediatrics, 133 (1), 37-45.
Participants: 15,612 toddlers
Summary:
This study validates the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F), a screening tool for low risk toddlers, and demonstrates improved utility compared with the original M-CHAT. The reliability and validity of the M-CHAT-R/F were demonstrated, and optimal scoring was determined by using receiver operating characteristic curves. Children whose total score was >3 initially and >2 after follow-up had a 47.5% risk of being diagnosed with autism spectrum disorder (ASD) and a 94.6% risk of any developmental delay or concern. Total score was more effective than alternative scores. An algorithm based on 3 risk levels is recommended to maximize clinical utility and to reduce age of diagnosis and onset of early intervention. The M-CHAT-R/F detects ASD at a higher rate compared with the M-CHAT while also reducing the number of children needing the follow-up. Children in the current study were diagnosed 2 years younger than the national median age of diagnosis.